Oxidative status of cardinal ligament in pelvic organ prolapse

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Effect of Estrogen on Oxidative Stress Response of Cardinal Ligament Fibroblasts from Women with or without Pelvic Organ Prolapse

Hypothesis / aims of study Production of reactive species, including free radicals, is an integral part of human metabolism. Because of its high potential to damage vital biological systems, reactive species have now been incriminated in aging and in more than 100 disease states. Estrogen has been proposed to exert antioxidant effects in in vitro models as well as in many biological systems. It...

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Pelvic organ prolapse.

Pelvic organ prolapse, or genital prolapse, is the descent of one or more of the pelvic structures (bladder, uterus, vagina) from the normal anatomic location toward or through the vaginal opening. Women of all ages may be affected, although pelvic organ prolapse is more common in older women. The cause is a loss of pelvic support from multiple factors, including direct injury to the levator an...

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Pelvic organ prolapse.

The separate disease entities that are included in the general term of pelvic organ prolapse have been discussed in detail in this chapter. The focus of discussion centered on the pathophysiology and clinical presentation of these conditions. At this point, the emergency physician should be able to properly recognize, assess, initiate treatment, and obtain appropriate referral in cases of pelvi...

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Pathophysiology of pelvic organ prolapse.

The pathophysiology of pelvic organ prolapse is believed to be multifactorial. Several risk factors, such as childbirth and aging, have been identified. Suspected aberrations in the structure and function of the connective tissue, muscles, and nerves of the pelvic floor are still under investigation. In this article, the cellular, biochemical, and molecular basis of pelvic organ prolapse is dis...

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ژورنال

عنوان ژورنال: Experimental and Therapeutic Medicine

سال: 2018

ISSN: 1792-0981,1792-1015

DOI: 10.3892/etm.2018.6633